Oshima K, Kanda Y, Nannya Y, Kaneko M, Hamaki T, Suguro M, Yamamoto R, Chizuka A, Matsuyama T, Takezako N, Miwa A, Togawa A, Niino H, Nasu M, Saito K, Morita T
Department of Hematology, International Medical Center of Japan, Tokyo, Japan.
Am J Hematol. 2001 May;67(1):1-5. doi: 10.1002/ajh.1067.
We studied clinical features and pathologic findings in 52 consecutively autopsied patients with multiple myeloma in our center between 1979 and 1998. Distant extraosseous involvement was found in 33 patients (63.5%). Thirty-one patients (59.6%) were proven to have infection at autopsy, among which pneumonia was most common site of infection. Amyloidosis was shown in 8 patients. Second malignancies were observed in 4 cases. The three major causes of death were hemorrhage, infection, and renal failure, which accounted for death in approximately 70% of the patients. Advances in the anticancer and antimicrobial chemotherapies might have decreased deaths due to myeloma itself or infection.
我们研究了1979年至1998年间在我们中心连续52例多发性骨髓瘤尸检患者的临床特征和病理结果。33例患者（63.5%）发现有远处骨外受累。31例患者（59.6%）在尸检时被证实有感染，其中肺炎是最常见的感染部位。8例患者显示有淀粉样变性。4例观察到第二原发恶性肿瘤。三大死亡原因是出血、感染和肾衰竭，约占患者死亡人数的70%。抗癌和抗菌化疗的进展可能减少了因骨髓瘤本身或感染导致的死亡。
