Madewell B R, Griffey S M, McEntee M C, Leppert V J, Munn R J
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis 95616, USA.
Vet Pathol. 2001 Mar;38(2):196-202. doi: 10.1354/vp.38-2-196.
Twenty feline vaccine-associated sarcomas were examined by transmission electron microscopy. Tumors contained pleomorphic spindle cells, histiocytoid cells, and giant cells. Most tumors contained myofibroblasts, which had morphologic features similar to those of fibroblasts. These cells were further distinguished by subplasmalemmal dense plaques and thin cytoplasmic actin myofilaments organized as elongated bundles concentrated at irregular intervals forming characteristic dense bodies. Intracellular crystalline particulate material was found in 5 of the 20 tumors. Energy dispersive X-ray spectroscopy was used to identify the crystalline material within one tumor as aluminum-based. One tumor from a feline leukemia virus-infected cat contained budding and immature retroviral particles.
通过透射电子显微镜检查了20例猫疫苗相关肉瘤。肿瘤包含多形性梭形细胞、组织细胞样细胞和巨细胞。大多数肿瘤含有肌成纤维细胞，其形态学特征与成纤维细胞相似。这些细胞通过质膜下致密斑和细的胞质肌动蛋白微丝进一步区分，这些微丝组织成细长束，以不规则间隔集中形成特征性致密体。在20个肿瘤中的5个中发现了细胞内结晶颗粒物质。能量色散X射线光谱法用于鉴定一个肿瘤内的结晶物质为铝基。一只感染猫白血病病毒的猫的一个肿瘤含有出芽和未成熟的逆转录病毒颗粒。
