Woodward Kevin N
Technology Sciences (Europe) Limited, Concordia House, St James Business Park, Grimbald Crag Court, Knaresborough, North Yorkshire, HG5 8QB, UK ; Intervet/Schering-Plough Animal Health, Breakspear Road South, Harefield, Uxbridge, Middlesex, UB9 6LS, UK.
ISRN Vet Sci. 2011 Apr 12;2011:210982. doi: 10.5402/2011/210982. Print 2011.
The etiology of feline injection-site sarcomas remains obscure. Sarcomas and other tumors are known to be associated with viral infections in humans and other animals, including cats. However, the available evidence suggests that this is not the case with feline injection-site sarcomas. These tumors have more in common with sarcomas noted in experimental studies with laboratory animals where foreign materials such as glass, plastics, and metal are the causal agent. Tumors arising with these agents are associated with chronic inflammation at the injection or implantation sites. Similar tumors have been observed, albeit infrequently, at microchip implantation sites, and these also are associated with chronic inflammation. It is suggested that injection-site sarcomas in cats may arise at the administration site as a result of chronic inflammation, possibly provoked by adjuvant materials, with subsequent DNA damage, cellular transformation, and clonal expansion. However, more fundamental research is required to elucidate the mechanisms involved.
猫注射部位肉瘤的病因仍不清楚。已知肉瘤和其他肿瘤与人类及包括猫在内的其他动物的病毒感染有关。然而，现有证据表明猫注射部位肉瘤并非如此。这些肿瘤与实验研究中用玻璃、塑料和金属等异物作为致病因素的实验动物身上发现的肉瘤有更多共同之处。由这些因素引发的肿瘤与注射或植入部位的慢性炎症有关。在微芯片植入部位也观察到了类似的肿瘤，尽管很少见，而且这些肿瘤也与慢性炎症有关。有人提出，猫的注射部位肉瘤可能是由于慢性炎症在给药部位产生的，可能是由佐剂材料引发的，随后导致DNA损伤、细胞转化和克隆性扩增。然而，需要进行更深入的研究来阐明其中涉及的机制。
