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猫疫苗相关性纤维肉瘤细胞系的建立及其在鸡胚绒毛尿囊膜上的生长——兽医肿瘤学研究的新体内模型。

Derivation of feline vaccine-associated fibrosarcoma cell line and its growth on chick embryo chorioallantoic membrane - a new in vivo model for veterinary oncological studies.

机构信息

Department of Small Animal Diseases with Clinic, Faculty of Veterinary Medicine, Warsaw University of Life Sciences - WULS, Nowoursynowska 159c, 02-776, Warsaw, Poland.

出版信息

Vet Res Commun. 2012 Dec;36(4):227-33. doi: 10.1007/s11259-012-9535-9. Epub 2012 Aug 15.

DOI:10.1007/s11259-012-9535-9
PMID:22893503
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3496557/
Abstract

Feline vaccine associated fibrosarcomas are the second most common skin tumor in cats. Methods of treatment are: surgery, chemotherapy and radiotherapy. Nevertheless, the usage of cytostatics in feline vaccine associated sarcoma therapy is limited due to their adverse side effects, high toxicity and low biodistribution after i.v. injection. Therefore, much research on new therapeutic drugs is being conducted. In human medicine, the chick embryo chorioallantoic membrane (CAM) model is used as a cheap and easy to perform assay to assess new drug effectiveness in cancer treatment. Various human cell lines have different tumors growth on CAM. In veterinary medicine such model has not been described yet. In the present article derivation of feline vaccine associated fibrosarcoma cell line and its growth on CAM is described. The cell line and the tumor grown were confirmed by histopathological and immunohistochemical examination. As far as we believe, this is the first attempt to create such model, which may be used for further in vivo studies in veterinary oncology.

摘要

猫疫苗相关性纤维肉瘤是猫中第二常见的皮肤肿瘤。治疗方法包括：手术、化疗和放疗。然而，由于细胞抑制剂的不良反应、高毒性和静脉注射后生物分布低，在猫疫苗相关性肉瘤治疗中的使用受到限制。因此，正在进行大量关于新治疗药物的研究。在人类医学中，鸡胚绒毛尿囊膜 (CAM) 模型被用作一种廉价且易于进行的测定方法，用于评估癌症治疗中新药物的有效性。各种人细胞系在 CAM 上具有不同的肿瘤生长。在兽医医学中，尚未描述这种模型。本文描述了猫疫苗相关性纤维肉瘤细胞系的衍生及其在 CAM 上的生长。通过组织病理学和免疫组织化学检查确认了细胞系和肿瘤的生长。据我们所知，这是首次尝试创建这种模型，它可用于兽医肿瘤学的进一步体内研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0c0/3496557/2852eb204583/11259_2012_9535_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0c0/3496557/960a13106cc3/11259_2012_9535_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0c0/3496557/1c36f349945d/11259_2012_9535_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0c0/3496557/99f87eebeca0/11259_2012_9535_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0c0/3496557/8e85b406881b/11259_2012_9535_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0c0/3496557/2852eb204583/11259_2012_9535_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0c0/3496557/960a13106cc3/11259_2012_9535_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0c0/3496557/1c36f349945d/11259_2012_9535_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0c0/3496557/99f87eebeca0/11259_2012_9535_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0c0/3496557/8e85b406881b/11259_2012_9535_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0c0/3496557/2852eb204583/11259_2012_9535_Fig5_HTML.jpg

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