Kim L M, Morley P S, Traub-Dargatz J L, Salman M D, Gentry-Weeks C
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523, USA.
J Am Vet Med Assoc. 2001 Mar 1;218(5):740-8. doi: 10.2460/javma.2001.218.740.
To evaluate factors potentially associated with fecal Salmonella shedding among equine patients hospitalized for colic at a veterinary teaching hospital and to determine the effects of probiotic treatment on fecal Salmonella shedding and clinical signs.
Longitudinal study and controlled trial.
246 equine colic patients.
History and medical information were obtained from patient records. Fecal and environmental samples were submitted for aerobic bacterial culture for Salmonella enterica. Fifty-one patients were treated with a commercially available probiotic; 46 were treated with a placebo. Logistic regression was used to evaluate data.
Salmonella organisms were detected in feces from 23 (9%) patients at least once during hospitalization. Patients were more likely to shed Salmonella organisms if diarrhea was evident < or = 6 hours after hospitalization and duration of hospitalization exceeded 8 days (odds ratio [OR], 20.3), laminitis developed during hospitalization (OR, 12.0), results of nasogastric intubation were abnormal (OR, 4.9), leukopenia was evident < or =6 hours after hospitalization (OR, 4.6), or travel time to the teaching hospital exceeded 1 hour (OR, 3.5). Horses treated with the probiotic did not differ from control horses in regard to likelihood of fecal Salmonella shedding (OR, 1.5) or prevalence of clinical signs.
Results suggest that certain risk factors are associated with fecal shedding of S enterica among equine patients hospitalized at a veterinary teaching hospital because of colic and that pathogen monitoring in patients and the hospital environment and use of barrier nursing precautions for equine colic patients are beneficial.
评估在一家兽医教学医院因急腹症住院的马属动物患者粪便中沙门氏菌排菌的潜在相关因素，并确定益生菌治疗对粪便沙门氏菌排菌及临床症状的影响。
纵向研究和对照试验。
246例马属动物急腹症患者。
从患者记录中获取病史和医疗信息。提交粪便和环境样本进行肠道沙门氏菌需氧菌培养。51例患者接受市售益生菌治疗；46例接受安慰剂治疗。采用逻辑回归分析数据。
23例（9%）患者在住院期间至少有一次粪便中检测到沙门氏菌。如果住院后腹泻在≤6小时内出现且住院时间超过8天（优势比[OR]，20.3）、住院期间发生蹄叶炎（OR，12.0）、鼻胃插管结果异常（OR，4.9）、住院后≤6小时出现白细胞减少（OR，4.6）或到教学医院的行程时间超过1小时（OR，3.5），患者排出沙门氏菌的可能性更大。接受益生菌治疗的马在粪便沙门氏菌排菌可能性（OR，1.5）或临床症状发生率方面与对照马无差异。
结果表明，某些危险因素与因急腹症在兽医教学医院住院的马属动物患者肠道沙门氏菌的粪便排菌有关，对患者和医院环境进行病原体监测以及对马属动物急腹症患者采取屏障护理预防措施是有益的。
