Mendiratta V, Sharma R C, Arya L, Sardana K
Department of Dermatology and STD, Lady Hardinge Medical College, New Delhi, India.
J Dermatol. 2001 Jan;28(1):58-9. doi: 10.1111/j.1346-8138.2001.tb00089.x.
Linear and whorled nevoid hypermelanosis (LWNHM) is a reticulate pigmentary disorder with a sporadic occurrence, representing genetic mosaicism. It is characterised by hyperpigmented macules in a reticulate pattern along Blaschko's lines, sparing the mucous membranes and stabilising after one to two years. It may be associated with various neurological abnormalities. The disorder may resemble incontinentia pigmenti, epidermal nevus, or zebra-like hyperpigmentation clinically. We report LWMNHM in a 15-year-old girl with progressively increasing streaks of reticulate hyperpigmented macules arranged in a whorled pattern over the trunk and extremities, which appeared soon after birth. There was no history of any preceding eruption or any associated systemic abnormality. Histopathological examination revealed basal cell hyperpigmentation without any pigmentary incontinence. CT scan of the brain was normal.
线状和涡状痣样黑素沉着过度（LWNHM）是一种散发性的网状色素沉着障碍，代表着遗传镶嵌现象。其特征为沿Blaschko线呈网状分布的色素沉着斑，不累及黏膜，一到两年后病情稳定。它可能与各种神经异常有关。该疾病在临床上可能类似于色素失禁症、表皮痣或斑马样色素沉着。我们报告了一名15岁女孩的LWNHM，其躯干和四肢出现呈涡状排列的网状色素沉着斑条纹且逐渐增多，出生后不久即出现。无任何先前皮疹史或任何相关的全身异常。组织病理学检查显示基底细胞色素沉着增加，但无色素失禁。脑部CT扫描正常。
