Kalter D C, Griffiths W A, Atherton D J
St. John's Hospital for Diseases of the Skin, London, England.
J Am Acad Dermatol. 1988 Dec;19(6):1037-44. doi: 10.1016/s0190-9622(88)70269-8.
Two cases are presented of congenital linear and whorled hypermelanosis. Hyperpigmented macules in streaky configurations along Blaschko's lines appeared gradually after birth. Histologic examination revealed prominent epidermal melanocytes and irregular basal layer hyperpigmentation with normal melanosomes. This condition must be differentiated from incontinentia pigmenti, early systematized epidermal nevus, extensive hypomelanosis of Ito, and chimerism. Other similar case reports from the literature suggest that incidence is sporadic and may be associated with more serious congenital anomalies. The patterning is the inverse to that found in hypomelanosis of Ito. Developmental somatic mosaicism may be responsible for this patterned hypermelanosis.
本文报告了两例先天性线状和涡状色素沉着过度病例。出生后，沿布拉斯科线呈条纹状分布的色素沉着斑逐渐出现。组织学检查显示表皮黑素细胞显著增多，基底层色素沉着不规则，但黑素小体正常。这种情况必须与色素失禁症、早期系统性表皮痣、伊藤广泛性色素减退症和嵌合体相鉴别。文献中的其他类似病例报告表明，其发病率为散发性，可能与更严重的先天性异常有关。其图案与伊藤色素减退症中的图案相反。发育性体细胞镶嵌现象可能是这种图案化色素沉着过度的原因。
