Rodríguez Holguín S, Corral M, Cadaveira F
Departamento de Psicoloxía Clínica e Psicobioloxía, facultade de Psicoloxía, Campus universitario Sur, Universidade de Santiago de Compostela, 15706, Santiago de Compostela, Galicia, Spain.
Neurophysiol Clin. 2001 Feb;31(1):40-7. doi: 10.1016/s0987-7053(00)00241-0.
In the course of a high-risk study for alcoholism, the middle-latency auditory evoked potentials (MAEPs) of children of alcoholics were explored.
A series of auditory clicks (0.1 ms, 60 dB SL, 1.1/s) were used to record the Pa and Pb peaks of the MAEPs in 15 children of alcoholics with a multigenerational family history of alcoholism, and 17 control subjects, ranging from 10 to 14 years of age.
The latency of Pb was shorter in the high-risk than in the control group, and there was also a significant risk group by age interaction on Pa latency. The amplitude of Pa was smaller in the children of alcoholics.
The characteristics of the MAEPs of the high-risk subjects did not match the pattern of abnormalities previously observed in chronic alcoholics, which are supposed to be a consequence of the neurotoxic effects of ethanol. Nonetheless, the results showed significant differences in MAEPs between children of alcoholics and controls, pointing to an anomalous pattern of information transmission from thalamus to cortex that should be further analyzed using larger samples in a broader age range.
在一项针对酒精中毒的高风险研究过程中，对酗酒者子女的中潜伏期听觉诱发电位（MAEP）进行了探究。
使用一系列听觉咔嗒声（0.1毫秒，60分贝感觉级，每秒1.1次）记录15名有酗酒多代家族史的酗酒者子女以及17名年龄在10至14岁的对照受试者的MAEP的Pa和Pb波峰。
高风险组中Pb的潜伏期比对照组短，并且在Pa潜伏期上年龄与风险组之间也存在显著交互作用。酗酒者子女的Pa波幅较小。
高风险受试者的MAEP特征与先前在慢性酗酒者中观察到的异常模式不匹配，后者被认为是乙醇神经毒性作用的结果。尽管如此，结果显示酗酒者子女与对照组之间的MAEP存在显著差异，表明从丘脑到皮层存在异常的信息传递模式，应在更广泛的年龄范围内使用更大样本进一步分析。
