Pereira C F, Middel J, Jansen G, Verhoef J, Nottet H S
Neuroimmunology Section, Eijkman-Winkler Institute, University Medical Center, HpG04.614, Heidelberglaan 100, NL-3584 CX, Utrecht, Netherlands.
J Neuroimmunol. 2001 Apr 2;115(1-2):168-75. doi: 10.1016/s0165-5728(01)00262-4.
The CX(3)C chemokine fractalkine was found to be up-regulated in the brain during inflammatory processes. In this study, we tried to assess the role of fractalkine in HIV-1-associated dementia. Fractalkine expression is up-regulated in the brains of AIDS patients with HAD. Fractalkine immunoreactivity was mainly detected in astrocytes. In addition, fractalkine expression was found to be up-regulated in cocultures of astrocytes and HIV-infected macrophages. This up-regulation was dependent on cell-cell contact. We propose that fractalkine produced during interactions between astrocytes and HIV-infected macrophages plays a role in HAD by regulating the trafficking of monocytic cells in the brain parenchyma.
CX(3)C趋化因子fractalkine在炎症过程中会在大脑中上调。在本研究中，我们试图评估fractalkine在HIV-1相关痴呆中的作用。Fractalkine表达在患有HIV相关痴呆（HAD）的艾滋病患者大脑中上调。Fractalkine免疫反应主要在星形胶质细胞中检测到。此外，在星形胶质细胞与HIV感染的巨噬细胞的共培养物中发现fractalkine表达上调。这种上调依赖于细胞间接触。我们提出，星形胶质细胞与HIV感染的巨噬细胞相互作用过程中产生的fractalkine通过调节脑实质中单核细胞的运输在HAD中发挥作用。
