Schwaeble W J, Stover C M, Schall T J, Dairaghi D J, Trinder P K, Linington C, Iglesias A, Schubart A, Lynch N J, Weihe E, Schäfer M K
Department of Microbiology and Immunology, University of Leicester, UK.
FEBS Lett. 1998 Nov 20;439(3):203-7. doi: 10.1016/s0014-5793(98)01384-2.
Fractalkine is the only as yet known member of a novel class of chemokines. Besides its novel Cys-X-X-X-Cys motif, fractalkine exhibits features which have not been described for any other member of the chemokine family, including its unusual size (397 amino acids human, 395 mouse) and the possession of a transmembrane anchor, from which a soluble form may be released by extracellular cleavage. This report demonstrates the abundant mRNA and fractalkine protein expression in neuronal cells. The neuronal expression of fractalkine mRNA is unaffected by experimentally induced inflammation of central nervous tissue.
趋化因子是一类新型趋化因子中目前唯一已知的成员。除了其新颖的Cys-X-X-X-Cys基序外，趋化因子还具有趋化因子家族其他成员所没有描述过的特征，包括其不寻常的大小（人类为397个氨基酸，小鼠为395个氨基酸）以及拥有一个跨膜锚定结构，通过细胞外裂解可从中释放出一种可溶性形式。本报告证明了神经元细胞中趋化因子mRNA和趋化因子蛋白的大量表达。趋化因子mRNA的神经元表达不受实验诱导的中枢神经组织炎症的影响。
