Hecker D, Rose H, Powitz A
Acta Histochem. 1979;64(1):113-23.
Within 5 days following treatment with cytostatics (vincristine, vinblastine, trenimon, 5-fluorouracil) enzyme-histochemical and ultrastructural changes occurred in the kidney and liver of Wistar rats. The enzyme activities were influenzed by cytostatics in different ways. It was found that the activity of some enzymes increased whereas that of others decreased. Kidney and liver showed a different response in their enzymatic behaviour. The cytostatics used did not have the same effect. The histochemical changes following injection of cytostatics in juvenile rats do not agree with those in adult ones. The electronmicroscopic findings reveal marked morphological changes of the kidney and liver cells within the first 5 days following injection of cytostatics. From the 8th day on after administration of cytostatics neither histochemical nor ultrastructural changes as compared with the controlls were found.
在用细胞抑制剂（长春新碱、长春碱、氮芥、5-氟尿嘧啶）治疗后的5天内，Wistar大鼠的肾脏和肝脏出现了酶组织化学和超微结构变化。细胞抑制剂以不同方式影响酶活性。发现一些酶的活性增加，而另一些酶的活性降低。肾脏和肝脏在酶行为方面表现出不同的反应。所使用的细胞抑制剂效果不同。给幼年大鼠注射细胞抑制剂后的组织化学变化与成年大鼠不同。电子显微镜检查结果显示，注射细胞抑制剂后的头5天内，肾脏和肝脏细胞出现明显的形态学变化。从注射细胞抑制剂后的第8天起，与对照组相比，未发现组织化学和超微结构变化。
