Hecker D, Rose H, Powitz A
Acta Histochem. 1978;62(1):95-109.
In 2 inoculated mouse tumours the conformity of the actions of 4 different cytostatics at 2 dose levels was tested in vitro and in vivo. The histochemical reaction of lactate dehydrogenase and NADH diaphorase was taken as a criterion of the cytostatic action. The investigations showed the tumours used responded to the cytostatics employed. A good conformity of the in vitro and in vivo findings was established. The histochemical assessment of organ cultures following the administration of cytostatics allows to determine the sensitivity of tumours and helps the physician in deciding on an effective therapeutic.
在2个接种的小鼠肿瘤中，在体外和体内测试了4种不同细胞抑制剂在2个剂量水平下作用的一致性。将乳酸脱氢酶和NADH黄递酶的组织化学反应作为细胞抑制作用的标准。研究表明，所使用的肿瘤对所采用的细胞抑制剂有反应。体外和体内研究结果具有良好的一致性。在给予细胞抑制剂后对器官培养物进行组织化学评估，有助于确定肿瘤的敏感性，并帮助医生决定有效的治疗方法。
