Tie受体：血管生成和淋巴管生成反应的新型调节剂。

Tie receptors: new modulators of angiogenic and lymphangiogenic responses.

作者信息

Jones N, Iljin K, Dumont D J, Alitalo K

机构信息

Department of Medical Biophysics, University of Toronto, Sunnybrook and Women's College Health Sciences Centre, 2075 Bayview Avenue, S-227, Toronto, Ontario, Canada M4N 3M5.

出版信息

Nat Rev Mol Cell Biol. 2001 Apr;2(4):257-67. doi: 10.1038/35067005.

DOI:10.1038/35067005

PMID:11283723

Abstract

Angiogenesis is required for normal embryonic vascular development and aberrant angiogenesis contributes to several diseases, including cancer, diabetes and tissue ischaemia. What are the molecular mechanisms that regulate this important process? The Tie family of receptors and their ligands, the angiopoietins, are beginning to provide insight into how vessels make decisions such as whether to grow or regress--processes that are important not only during development but throughout an organism's life.

摘要

血管生成是正常胚胎血管发育所必需的，而异常的血管生成会导致多种疾病，包括癌症、糖尿病和组织缺血。调节这一重要过程的分子机制是什么？Tie受体家族及其配体血管生成素，正开始为血管如何做出诸如生长或退化等决定提供见解——这些过程不仅在发育过程中很重要，而且在生物体的整个生命过程中都很重要。