使用聚（2-吡啶甲酸）修饰玻碳电极电化学测定多巴胺

Electrochemical determination of dopamine using a poly(2-picolinic acid) modified glassy carbon electrode.

作者信息

Zhao H, Zhang Y, Yuan Z

机构信息

Department of Chemistry, Graduate School of Chinese Academy of Sciences, Beijing 100039, China.

出版信息

Analyst. 2001 Mar;126(3):358-60. doi: 10.1039/b008283j.

DOI:10.1039/b008283j

PMID:11284339

Abstract

A poly(2-picolinic acid) chemically modified electrode (CME) for the determination of dopamine (DA) by cyclic voltammetry is described. Compared with a bare glassy carbon electrode, the CME exhibits a 200 mV shift of the oxidation potential of DA in the cathodic direction and a marked enhancement of the current response. In pH 7.0 buffer solution, a linear calibration graph is obtained over the range from 2.5 x 10(-7) to 1.0 x 10(-5) mol dm-3 with a correlation coefficient of 0.998. The detection limit is 3.0 x 10(-8) mol dm-3. The modified electrode eliminated efficiently the interference from ascorbic acid (AA) when present in a 150-fold concentration ratio. It also showed excellent stability and reproducibility.

摘要

描述了一种用于通过循环伏安法测定多巴胺（DA）的聚（2-吡啶甲酸）化学修饰电极（CME）。与裸玻碳电极相比，CME使DA的氧化电位在阴极方向上有200 mV的偏移，并使电流响应显著增强。在pH 7.0缓冲溶液中，在2.5×10⁻⁷至1.0×10⁻⁵ mol dm⁻³范围内获得线性校准曲线，相关系数为0.998。检测限为3.0×10⁻⁸ mol dm⁻³。当抗坏血酸（AA）以150倍浓度比存在时，修饰电极有效地消除了其干扰。它还表现出优异的稳定性和重现性。