• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

DR, DQ, and you: MHC alleles and autoimmunity.

作者信息

Sønderstrup G, McDevitt H O

机构信息

Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305-5124, USA.

出版信息

J Clin Invest. 2001 Apr;107(7):795-6. doi: 10.1172/JCI12634.

DOI:10.1172/JCI12634
PMID:11285296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC199583/
Abstract
摘要

相似文献

1
DR, DQ, and you: MHC alleles and autoimmunity.DR、DQ与自身免疫：MHC等位基因与自身免疫
J Clin Invest. 2001 Apr;107(7):795-6. doi: 10.1172/JCI12634.
2
HLA-DQB1 alleles may influence the surface expression of DQ molecules in lymphomononuclear cells of type 1 diabetes mellitus patients.HLA - DQB1等位基因可能影响1型糖尿病患者淋巴细胞单核细胞中DQ分子的表面表达。
Scand J Immunol. 2004 Mar;59(3):305-9. doi: 10.1111/j.0300-9475.2004.01386.x.
3
Modulatory role of DR4- to DQ8-restricted CD4 T-cell responses and type 1 diabetes susceptibility.DR4至DQ8限制的CD4 T细胞反应的调节作用与1型糖尿病易感性
Diabetes. 2006 Dec;55(12):3455-62. doi: 10.2337/db06-0680.
4
The regulatory role of DR4 in a spontaneous diabetes DQ8 transgenic model.DR4在自发性糖尿病DQ8转基因模型中的调节作用。
J Clin Invest. 2001 Apr;107(7):871-80. doi: 10.1172/JCI11708.
5
[HLA complex and susceptibility to insulin-dependent diabetes].
Presse Med. 1990;19(28):1303-4.
6
[Mechanism and genetic control of the autoimmune response directed against beta-pancreatic cells in insulin-dependent diabetes].[胰岛素依赖型糖尿病中针对β胰腺细胞的自身免疫反应的机制与遗传控制]
Journ Annu Diabetol Hotel Dieu. 1985:171-82.
7
HLA and insulin-dependent diabetes mellitus.
Nature. 1989 Feb 2;337(6206):415. doi: 10.1038/337415a0.
8
Molecular properties of HLA-DQ alleles conferring susceptibility to or protection from insulin-dependent diabetes mellitus: keys to the fate of islet beta-cells.赋予胰岛素依赖型糖尿病易感性或保护性的HLA - DQ等位基因的分子特性：胰岛β细胞命运的关键
Am J Med Genet. 2002 May 30;115(1):37-47. doi: 10.1002/ajmg.10342.
9
Cytokines pre-determined by genetic factors are involved in pathogenesis of Rheumatoid arthritis.由遗传因素预先决定的细胞因子参与类风湿性关节炎的发病机制。
Cytokine. 2015 Oct;75(2):216-21. doi: 10.1016/j.cyto.2014.11.028. Epub 2014 Dec 23.
10
Soluble, dimeric HLA DR4-peptide chimeras: an approach for detection and immunoregulation of human type-1 diabetes.可溶性二聚体 HLA DR4-肽嵌合体：一种检测和免疫调节人类 1 型糖尿病的方法。
Eur J Immunol. 2005 Sep;35(9):2762-75. doi: 10.1002/eji.200526158.

引用本文的文献

1
HLA-DRB1 and DQB1 Allelic Polymorphism and Multiple Sclerosis in a Moroccan Population.摩洛哥人群中 HLA - DRB1 和 DQB1 等位基因多态性与多发性硬化症
Curr Issues Mol Biol. 2025 Jun 13;47(6):458. doi: 10.3390/cimb47060458.
2
Vaccine-induced autoimmunity: the role of molecular mimicry and immune crossreaction.疫苗诱导的自身免疫：分子模拟和免疫交叉反应的作用。
Cell Mol Immunol. 2018 Jun;15(6):586-594. doi: 10.1038/cmi.2017.151. Epub 2018 Mar 5.
3
A novel human autoantigen, endothelial cell growth factor, is a target of T and B cell responses in patients with Lyme disease.一种新型人类自身抗原——内皮细胞生长因子，是莱姆病患者T细胞和B细胞反应的靶点。
Arthritis Rheum. 2013 Jan;65(1):186-96. doi: 10.1002/art.37732.
4
Fcγ receptor IIB (FcγRIIB) maintains humoral tolerance in the human immune system in vivo.Fcγ 受体 IIB（FcγRIIB）在体内维持人类免疫系统的体液耐受。
Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18772-7. doi: 10.1073/pnas.1111810108. Epub 2011 Nov 7.
5
Synthesis and evaluation of 99mTc-labelled monoclonal antibody 1D09C3 for molecular imaging of major histocompatibility complex class II protein expression.99mTc 标记单克隆抗体 1D09C3 的合成与评价及其用于主要组织相容性复合体 II 类蛋白表达的分子成像。
Mol Imaging Biol. 2011 Oct;13(5):930-9. doi: 10.1007/s11307-010-0407-9.
6
Overview of the immune response.免疫反应概述。
J Allergy Clin Immunol. 2010 Feb;125(2 Suppl 2):S3-23. doi: 10.1016/j.jaci.2009.12.980.
7
Lymphocytes, neuropeptides, and genes involved in alopecia areata.斑秃中涉及的淋巴细胞、神经肽和基因。
J Clin Invest. 2007 Aug;117(8):2019-27. doi: 10.1172/JCI31942.

本文引用的文献

1
The regulatory role of DR4 in a spontaneous diabetes DQ8 transgenic model.DR4在自发性糖尿病DQ8转基因模型中的调节作用。
J Clin Invest. 2001 Apr;107(7):871-80. doi: 10.1172/JCI11708.
2
Co-expression of HLA DR3 and DQ8 results in the development of spontaneous insulitis and loss of tolerance to GAD65 in transgenic mice.HLA DR3和DQ8的共表达导致转基因小鼠发生自发性胰岛炎并丧失对谷氨酸脱羧酶65（GAD65）的耐受性。
Diabetes. 2000 Apr;49(4):548-54. doi: 10.2337/diabetes.49.4.548.
3
Complementation between specific HLA-DR and HLA-DQ genes in transgenic mice determines susceptibility to experimental autoimmune encephalomyelitis.转基因小鼠中特定HLA-DR和HLA-DQ基因之间的互补作用决定了对实验性自身免疫性脑脊髓炎的易感性。
Hum Immunol. 2000 Mar;61(3):279-89. doi: 10.1016/s0198-8859(99)00135-4.
4
HLA class II transgenic mice: models of the human CD4+ T-cell immune response.
Immunol Rev. 1999 Dec;172:335-43. doi: 10.1111/j.1600-065x.1999.tb01377.x.
5
In vivo evidence for the contribution of human histocompatibility leukocyte antigen (HLA)-DQ molecules to the development of diabetes.人类组织相容性白细胞抗原（HLA）-DQ分子对糖尿病发生作用的体内证据。
J Exp Med. 2000 Jan 3;191(1):97-104. doi: 10.1084/jem.191.1.97.
6
The role of MHC class II molecules in susceptibility and resistance to autoimmunity.MHC II类分子在自身免疫易感性和抗性中的作用。
Curr Opin Immunol. 1998 Dec;10(6):677-81. doi: 10.1016/s0952-7915(98)80088-5.
7
Modulation of HLA-DQ-restricted collagen-induced arthritis by HLA-DRB1 polymorphism.HLA-DRB1基因多态性对HLA-DQ限制的胶原诱导性关节炎的调节作用
Int Immunol. 1998 Oct;10(10):1449-57. doi: 10.1093/intimm/10.10.1449.
8
Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(alpha1*0101,beta1*0401) transgenic mice.利用HLA-DR（α1*0101，β1*0401）转基因小鼠鉴定人谷氨酸脱羧酶65的免疫显性T细胞表位。
Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8082-7. doi: 10.1073/pnas.94.15.8082.
9
Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients.近期发病的胰岛素依赖型糖尿病患者的T淋巴细胞对在HLA-DR等位基因背景下呈递的谷氨酸脱羧酶天然加工的T细胞表位的鉴定。
J Clin Invest. 1997 May 15;99(10):2405-15. doi: 10.1172/JCI119423.
10
HLA-encoded genetic predisposition in IDDM: DR4 subtypes may be associated with different degrees of protection.胰岛素依赖型糖尿病中HLA编码的遗传易感性：DR4亚型可能与不同程度的保护作用相关。
Diabetes. 1997 Jan;46(1):143-9. doi: 10.2337/diab.46.1.143.