McDevitt H O
Departments of Microbiology and Immunology, and of Medicine Stanford University School of Medicine Stanford CA 94305-5402 USA.
Curr Opin Immunol. 1998 Dec;10(6):677-81. doi: 10.1016/s0952-7915(98)80088-5.
The mechanism by which particular MHC class II alleles mediate susceptibility to a given autoimmune disease is unknown. During the past year, reports have indicated that the effects of MHC class II alleles which protect against type I diabetes in the nonobese diabetic mouse strain may, in some cases, be due to negative selection of diabetogenic T cell receptors and, in other cases, to positive selection of other T cells with a suppressive action on the diabetic process. Progress towards understanding the mechanisms of susceptibility continues to lag.
特定的主要组织相容性复合体（MHC）II类等位基因介导对特定自身免疫性疾病易感性的机制尚不清楚。在过去的一年里，有报告指出，在非肥胖糖尿病小鼠品系中，那些对I型糖尿病具有保护作用的MHC II类等位基因的效应，在某些情况下，可能是由于对致糖尿病性T细胞受体的阴性选择，而在其他情况下，则是由于对糖尿病进程具有抑制作用的其他T细胞的阳性选择。在理解易感性机制方面的进展仍然滞后。
