Boyd A S, King L E
Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Am J Dermatopathol. 2001 Apr;23(2):136-8. doi: 10.1097/00000372-200104000-00009.
Despite lupus erythematosus (LE) being considered a "connective tissue disease," little has been written about the elastic fiber changes in the skin of affected patients. We report our histologic findings in two patients with unusual cutaneous lesions. Elastic fiber loss was noted, and scattered giant cells with elastic fiber phagocytosis were prominent in one patient. The findings are similar to those described for middermal elastolysis. Other authors have reported patients with LE and elastic fiber loss resembling anetoderma. We believe that a spectrum of elastic fiber changes can occur in patients with LE and may be induced by infiltrating lymphocytes and/or circulating antibodies.
尽管红斑狼疮（LE）被视为一种“结缔组织病”，但关于该病患者皮肤中弹性纤维变化的报道却很少。我们报告了两名患有不寻常皮肤病变患者的组织学研究结果。在其中一名患者中发现了弹性纤维缺失，并且有散在的吞噬弹性纤维的巨细胞较为突出。这些发现与中层弹性纤维溶解症所描述的情况相似。其他作者也曾报道过红斑狼疮患者出现类似皮肤松弛症的弹性纤维缺失。我们认为，红斑狼疮患者可能会出现一系列弹性纤维变化，这些变化可能是由浸润的淋巴细胞和/或循环抗体所诱发的。
