Hoang Nguyen, Jibbe Atieh, Fraga Garth, Rajpara Anand
Department of Dermatology, University of Kansas Medical Center, Kansas City, KS.
Dermatol Online J. 2020 Apr 15;26(4):13030/qt1ws2x7fg.
Mid-dermal elastolysis is a rare acquired elastic tissue disorder with about 100 cases reported in the literature. It is characterized by localized patches of finely wrinkled skin on the shoulder and upper extremities and a band-like loss of elastic tissue in the mid-dermal layer on biopsy. Some patients may have symptoms of discomfort, erythema, and/or pruritis. Mid-dermal elastolysis is predominantly seen in young to middle-aged Caucasian females and extensive skin involvement may lead to cosmetic concerns. Furthermore, it is important to rule out other disorders of elastic fiber that are associated with systemic involvement. We present a case of MDE, discuss the differential diagnosis, and describe characteristic clinical features and histology findings of each condition.
真皮中部弹性纤维松解症是一种罕见的获得性弹性组织疾病，文献报道约有100例。其特征为肩部和上肢出现局部细小皱纹的皮肤斑块，活检显示真皮中层弹性组织呈带状缺失。部分患者可能有不适、红斑和/或瘙痒症状。真皮中部弹性纤维松解症主要见于年轻至中年的白种女性，广泛的皮肤受累可能导致美容问题。此外，排除其他与全身受累相关的弹性纤维疾病很重要。我们报告一例真皮中部弹性纤维松解症病例，讨论鉴别诊断，并描述每种情况的特征性临床特征和组织学表现。
