Kirsner R S, Falanga V
Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, FL 33136.
J Am Acad Dermatol. 1992 Nov;27(5 Pt 2):832-4. doi: 10.1016/0190-9622(92)70259-i.
Mid-dermal elastolysis is a rare disorder that is manifested clinically by wrinkling and histologically by the selective absence of elastic fibers in the mid dermis. We describe a young woman who developed abnormal wrinkling after augmentation mammoplasty with silicone implants. Histologic examination confirmed the diagnosis of mid-dermal elastolysis. In addition, a positive antinuclear antibody titer and a false-positive Lyme titer were subsequently detected. In a previously reported case a patient who had mid-dermal elastolysis also had an unusual false-positive pattern for Lyme disease. Silicone mammoplasty has been associated with connective tissue diseases. This report adds mid-dermal elastolysis to the list of diseases associated with augmentation mammoplasty and, along with the presence of autoantibodies, supports autoimmune involvement in mid-dermal elastolysis.
真皮中层弹性组织溶解症是一种罕见的疾病，临床特征为皮肤起皱，组织学特征为真皮中层弹性纤维选择性缺失。我们报告一名年轻女性，在硅胶植入隆乳术后出现异常皱纹。组织学检查确诊为真皮中层弹性组织溶解症。此外，随后检测到抗核抗体滴度阳性和莱姆病滴度假阳性。在之前报道的一例病例中，一名患有真皮中层弹性组织溶解症的患者也出现了不寻常的莱姆病假阳性模式。硅胶隆乳术与结缔组织疾病有关。本报告将真皮中层弹性组织溶解症添加到与隆乳术相关的疾病列表中，并且结合自身抗体的存在，支持自身免疫参与真皮中层弹性组织溶解症的发病机制。
