Appay V, Rowland-Jones S L
Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, OX3 9DS, Oxford, UK.
Trends Immunol. 2001 Feb;22(2):83-7. doi: 10.1016/s1471-4906(00)01812-3.
The activity of the chemokine RANTES is not restricted merely to chemotaxis. It is a powerful leukocyte activator, a feature potentially relevant in a range of inflammatory disorders. RANTES has attracted attention because it can potently suppress and, in some circumstances, enhance HIV replication. These characteristics are critically dependent on its ability to self-aggregate and bind to glycosaminoglycans.
趋化因子调节激活正常T细胞表达和分泌因子（RANTES）的活性不仅限于趋化作用。它是一种强大的白细胞激活剂，这一特性在一系列炎症性疾病中可能具有相关性。RANTES引起了人们的关注，因为它可以有效抑制并在某些情况下增强HIV复制。这些特性严重依赖于其自我聚集和结合糖胺聚糖的能力。
