Brook M G, Miller R F
Patrick Clements Clinic, Department of GUM/HIV, Central Middlesex Hospital, Acton Lane, London NW10 7NS, UK.
Sex Transm Infect. 2001 Apr;77(2):97-100. doi: 10.1136/sti.77.2.97.
To describe current knowledge on the aetiology, pathology, diagnosis, and treatment of HIV associated nephropathy.
A Medline search was performed using the key words "HIV," "nephropathy," "renal," and "kidney." A further search was performed for each of the currently licensed antiretroviral agents linked to key words "renal" or "kidney" and also using the MeSH heading "pharmacokinetics."
HIV associated nephropathy is a common complication of HIV in black African and Afro-Caribbean patients and presents with progressive renal failure and heavy proteinuria. As other causes of renal failure are likely to fall in incidence among patients successfully treated with highly active antiretroviral therapy (HAART), HIV associated nephropathy will become increasingly prominent as a cause of renal impairment in HIV infected patients. Recent evidence suggests that HIV associated nephropathy will respond to HAART with a dramatic improvement in renal function.
HIV associated nephropathy is a treatable condition. This condition should be actively sought in HIV infected patients if they are to receive the benefits of therapy.
描述目前关于人类免疫缺陷病毒（HIV）相关性肾病的病因、病理、诊断及治疗的知识。
使用关键词“HIV”“肾病”“肾脏的”和“肾”进行医学文献数据库（Medline）检索。对每种目前已获许可的抗逆转录病毒药物，分别使用关键词“肾脏的”或“肾”并结合医学主题词表（MeSH）中的“药代动力学”进行进一步检索。
HIV相关性肾病是非洲黑人及非洲裔加勒比海地区患者中HIV的常见并发症，表现为进行性肾衰竭和大量蛋白尿。随着其他肾衰竭病因在接受高效抗逆转录病毒治疗（HAART）的患者中发病率可能下降，HIV相关性肾病将日益成为HIV感染患者肾功能损害的一个突出原因。最近的证据表明，HIV相关性肾病对HAART有反应，肾功能会显著改善。
HIV相关性肾病是一种可治疗的疾病。如果HIV感染患者要从治疗中获益，就应积极筛查这种疾病。
