Almér L O, Pandolfi M, Osterlin S
Ophthalmologica. 1975;170(4):353-61. doi: 10.1159/000307233.
The fibrinolytic system has been studied in 168 patients with diabetes mellitus (DM) and compared to that of a group of 153 sex- and age-matched control subjects. The following determination were made: spontaneous fibrinolytic activity of the blood; fibrinolytic response to standardized venous stasis (stimulated fibrinolytic activity, "fibrinolytic capacity"); histochemical determination of fibrinolytic activators in the walls of superficial veins collected by biopsy. Diabetic patients were found as a group to have an impaired fibrinolytic system with the above fibrinolytic parameters decreased to various degrees in comparison with those of the controls. Less clear differences were observed between patients with and without ophthalmoscopically visible diabetic changes of the retina. However, patients with beginning angiopathy were found to have a significantly higher amount of fibrinolytic activators in their vessel walls than patients with more advanced retinopathy and without ophthalmoscopically detectable retinopathy. Furthermore, unlike patients without retinopathy, patients with retinopathy increased less or did not increase at all their spontaneous and stimulated fibrinolytic activity along the duration of the disease. The defective fibrinolytic system of diabetic patients may contribute to the occurrence of the vascular complications frequently seen in this disease. In the diabetic group, those patients who develop retinopathy show an impaired fibrinolytic defense with the duration of the disease.
对168例糖尿病患者的纤溶系统进行了研究，并与153名年龄和性别匹配的对照受试者的纤溶系统进行了比较。进行了以下测定：血液的自发纤溶活性；对标准化静脉淤滞的纤溶反应（刺激纤溶活性，“纤溶能力”）；通过活检收集的浅表静脉壁中纤溶激活剂的组织化学测定。结果发现，与对照组相比，糖尿病患者作为一个群体的纤溶系统受损，上述纤溶参数不同程度降低。在有和没有眼底可见糖尿病视网膜病变的患者之间观察到的差异不太明显。然而，发现有早期血管病变的患者血管壁中的纤溶激活剂含量明显高于有更晚期视网膜病变且无眼底可检测到视网膜病变的患者。此外，与没有视网膜病变的患者不同，患有视网膜病变的患者在疾病过程中自发和刺激的纤溶活性增加较少或根本没有增加。糖尿病患者纤溶系统缺陷可能导致该疾病中常见的血管并发症的发生。在糖尿病组中，那些发生视网膜病变的患者在疾病过程中表现出纤溶防御受损。
