大鼠肝脏匀浆对1-苯基-2-（正丙氨基）丙烷（N-丙基苯丙胺）的体外代谢
In vitro metabolism of 1-phenyl-2-(n-propylamino) propane (N-propylamphetamine) by rat liver homogenates.
作者信息
Coutts R T, Dawson G W, Beckett A H
出版信息
J Pharm Pharmacol. 1976 Nov;28(11):815-21. doi: 10.1111/j.2042-7158.1976.tb04063.x.
Abstract
In vitro incubation of (+/-)-N-(n-propyl)amphetamine (NPA) with the 12000 g supernatant fraction of rat liver hmogenate resulted in the formation of two N-oxygenated products identified as N-hydroxy-1-phenyl-2(n-propylamino)propane and N-[(1-methyl-2-phenyl) ethyl]-1-propanamine N-oxide by g.l.c., g.l.c.-m.s. and t.l.c. Amphetamine, phenylacetone,...
摘要
将（±）-N-（正丙基）苯丙胺（NPA）与大鼠肝脏匀浆12000g上清液组分进行体外温育，通过气相色谱、气相色谱-质谱联用和薄层层析，生成了两种N-氧化产物，分别鉴定为N-羟基-1-苯基-2（正丙基氨基）丙烷和N-[(1-甲基-2-苯基)乙基]-1-丙胺N-氧化物。苯丙胺、苯丙酮，...
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