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微小毛霉对(±)-N-(正丙基)苯丙胺的代谢

Metabolism of (+/-)-N-(n-propyl) amphetamine by Cunninghamella echinulata.

作者信息

Coutts R T, Foster B C, Jones G R, Myers G E

出版信息

Appl Environ Microbiol. 1979 Mar;37(3):429-32. doi: 10.1128/aem.37.3.429-432.1979.

Abstract

(+/-)-N-(n-propyl) amphetamine (I), a secondary amine, was readily metabolized by Cumminghamella echinulata. The products included known C- and N-oxygenated mammalian metabolites as well as N-acetylamphetamine and were identified by gas chromatography and mass spectrometry.

摘要

(±)-N-(正丙基)苯丙胺(I),一种仲胺,很容易被刺孢小克银汉霉代谢。产物包括已知的碳和氮氧化的哺乳动物代谢物以及N-乙酰苯丙胺,并通过气相色谱和质谱进行了鉴定。

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本文引用的文献

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Monooxygenase activity in Cunninghamella bainieri: evidence for a fungal system similar to liver microsomes.
Arch Biochem Biophys. 1973 May;156(1):97-103. doi: 10.1016/0003-9861(73)90345-7.
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Tryptophol formation by Zygosaccharomyces priorianus.普里阿努斯接合酵母形成色醇的过程。
Appl Microbiol. 1973 Jul;26(1):98-105. doi: 10.1128/am.26.1.98-105.1973.
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Microbial models of mammalian metabolism. Aromatic hydroxylation.
Arch Biochem Biophys. 1974 Apr 2;161(2):551-8. doi: 10.1016/0003-9861(74)90338-5.
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Microbial models of mammalian metabolism.
J Pharm Sci. 1975 Nov;64(11):1737-59. doi: 10.1002/jps.2600641104.

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