Camargos E R, Franco D J, Garcia C M, Dutra A P, Teixeira A L, Chiari E, Machado C R
Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Am J Trop Med Hyg. 2000 May;62(5):604-12. doi: 10.4269/ajtmh.2000.62.604.
We tested four isolates of Trypanosoma cruzi to assess parasite virulence and ability to cause myocarditis, cardiac sympathetic denervation, and histopathologic alterations in organs of the digestive system. The susceptibility of rats depends on the population of T. cruzi, with the ABC strain and the CL-Brener clone killing all animals, regardless of the parasitemic pattern. All tested T. cruzi populations caused acute myocarditis, but failed to induce histologic alterations in the intestine. The Cl-Brener and ABC isolates caused esophageal myositis. The myocarditis caused by the ABC, CL-Brener, and Y isolates was severe, but resolution started at the end of the acute phase. In contrast, the Col 1.7 G2 clone induced mild and sustained myocarditis. Our results also showed that T. cruzi populations able to induce severe acute myocarditis caused marked sympathetic denervation, but recovery of normal cardiac histology and innervation occurred. The sustained myocarditis induced by Col 1.7 G2 clone failed to cause sustained denervation.
我们检测了四种克氏锥虫分离株，以评估寄生虫的毒力以及引发心肌炎、心脏交感神经去神经支配和消化系统器官组织病理学改变的能力。大鼠的易感性取决于克氏锥虫的种群，ABC株和CL-Brener克隆会杀死所有动物，无论其寄生虫血症模式如何。所有测试的克氏锥虫种群均引发了急性心肌炎，但未在肠道中诱导组织学改变。Cl-Brener和ABC分离株引发了食管肌炎。由ABC、CL-Brener和Y分离株引起的心肌炎较为严重，但在急性期结束时开始消退。相比之下，Col 1.7 G2克隆诱发了轻度且持续的心肌炎。我们的结果还表明，能够诱发严重急性心肌炎的克氏锥虫种群会导致明显的交感神经去神经支配，但心脏组织学和神经支配会恢复正常。由Col 1.7 G2克隆诱发的持续性心肌炎并未导致持续性去神经支配。
