Lorenzo M E, Ploegh H L, Tirabassi R S
Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Semin Immunol. 2001 Feb;13(1):1-9. doi: 10.1006/smim.2000.0290.
Evasion of the immune system by viruses is a well-studied field. It remains a challenge to understand how these viral tactics affect pathogenesis and the viral lifecycle. At the same time, the study of viral proteins involved in immune evasion has helped us to better understand a number of cellular processes at the molecular level. Here we review recent data on different viral tactics for immune evasion and highlight what these viral interventions might teach us about cell biology.
病毒对免疫系统的逃避是一个研究充分的领域。理解这些病毒策略如何影响发病机制和病毒生命周期仍然是一项挑战。与此同时,对参与免疫逃避的病毒蛋白的研究帮助我们在分子水平上更好地理解了许多细胞过程。在此,我们综述了关于不同病毒免疫逃避策略的最新数据,并强调这些病毒干预措施可能会让我们对细胞生物学有哪些了解。