Hasin D, Paykin A, Endicott J
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.
Alcohol Clin Exp Res. 2001 Mar;25(3):411-4.
The role of positive family history in the etiology of alcohol dependence has been demonstrated repeatedly but little is known about the effect of this risk factor on the chronicity of alcohol dependence once it has begun.
We studied the effects of parental and sibling history in conjunction with frequency of binge drinking in a sample of 169 community residents who met criteria for DSM-IV alcohol dependence at the baseline interview. Subjects were re-interviewed approximately 1 year later and the status of their alcohol-dependence disorders (remitted or chronic) was determined.
Parental history of alcoholism was significantly related to chronicity of alcohol dependence, as was frequency of binge drinking.
Failure to find an effect for family history on chronicity would have suggested that the effect was transient, perhaps interacting with time-limited environmental vulnerability. The finding of a positive relationship between family history and chronicity suggests that the relationship between familial/ genetic background and alcohol dependence is stable.
阳性家族史在酒精依赖病因学中的作用已被反复证实，但对于这一风险因素在酒精依赖一旦发生后对其慢性化的影响却知之甚少。
我们在169名社区居民样本中研究了父母及兄弟姐妹的家族史以及暴饮频率的影响，这些居民在基线访谈时符合DSM-IV酒精依赖标准。大约1年后对受试者进行再次访谈，并确定其酒精依赖障碍的状态（缓解或慢性）。
酗酒的父母家族史与酒精依赖的慢性化显著相关，暴饮频率也是如此。
若未发现家族史对慢性化有影响，则表明这种影响是短暂的，可能与限时的环境易感性相互作用。家族史与慢性化之间呈正相关这一发现表明家族/遗传背景与酒精依赖之间的关系是稳定的。
