Dickerman R D, Jaikumar S
Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
Clin Neuropharmacol. 2001 Jan-Feb;24(1):62-4. doi: 10.1097/00002826-200101000-00011.
Hiccups have been classified as a neurologic reaction triggered by a multitude of factors. There are only a few reports of persistent hiccups associated with oral and intravenous corticosteroid use in the medical literature. It has been proposed that corticosteroids lower the threshold for synaptic transmission in the midbrain and directly stimulate the hiccup reflex arc. There is a recent report of progesterone-induced hiccups, which were thought to occur secondary to the glucocorticoid-like effects of progesterone on the brainstem. We report the first case of anabolic steroid-induced hiccups occurring in an elite power lifter. The hiccups occurred within 12 hours of the individual increasing his doses of oral anabolic steroids and persisted for 12 consecutive hours until medical attention was sought. In this report the pathophysiology of anabolic steroid-induced hiccups is discussed, and the postulated relationships of steroids and the hiccup reflex arc reviewed.
打嗝已被归类为由多种因素引发的神经学反应。医学文献中仅有少数关于口服和静脉使用皮质类固醇导致持续性打嗝的报告。有人提出，皮质类固醇会降低中脑突触传递的阈值，并直接刺激打嗝反射弧。最近有一份关于孕酮诱发打嗝的报告，认为这是由于孕酮对脑干的糖皮质激素样作用继发所致。我们报告了首例发生在一名精英力量举运动员身上的合成代谢类固醇诱发打嗝的病例。打嗝在该个体增加口服合成代谢类固醇剂量后的12小时内出现，并持续了12个小时，直到寻求医疗帮助。本报告讨论了合成代谢类固醇诱发打嗝的病理生理学，并对类固醇与打嗝反射弧之间的假定关系进行了综述。
