Arts I C, Hollman P C, Bueno De Mesquita H B, Feskens E J, Kromhout D
National Institute of Public Health and the Environment (RIVM), Department of Chronic Diseases Epidemiology, PO Box 1, NL-3720 BA Bilthoven, The Netherlands.
Int J Cancer. 2001 Apr 15;92(2):298-302. doi: 10.1002/1097-0215(200102)9999:9999<::aid-ijc1187>3.0.co;2-8.
The flavonoids, a group of more than 4,000 polyphenolic antioxidants, are potential cancer preventive components of fruits and vegetables. Catechins, one of the 6 major groups of flavonoids, are present in high concentrations in tea as well. Our objective was to evaluate the association between intake of catechins and incidence of epithelial cancers with data from the Zutphen Elderly Study, a prospective cohort study among 728 men aged 65-84 years in 1985. The average catechin intake at baseline was 72 mg/day (range, 0-355 mg/day). After 10 years of follow-up, 96 incident epithelial cancers were recorded, including 42 cases of lung cancer. After multivariate adjustment, catechin intake was not associated with epithelial cancer (risk ratio [RR] from lowest to highest tertile: 1.00, 0.75, 0.94; p for trend: 0.82), or lung cancer (RR from lowest to highest tertile: 1.00, 0.72, 0.92; p for trend: 0.80). Catechins not from tea were borderline significantly inversely associated with lung cancer incidence (RR and 95% confidence interval [CI] for a 7.5-mg increase in intake: 0.66, 0.42-1.05), whereas catechins from tea were not. Catechins from apple, the major source of non-tea catechins, were also related to lung cancer incidence (RR and 95% CI for a 7.5-mg catechin increase: 0.67, 0.38-1.17). Because tea, the major catechin source in this population, was not associated with cancer risk, it seems unlikely that catechins are responsible for the observed inverse trend between non-tea catechins and lung cancer incidence. However, differences in bioavailability of the various catechins may play a role; effects on individual cancer sites cannot be excluded and merit further investigation.
黄酮类化合物是一组超过4000种的多酚类抗氧化剂，是水果和蔬菜中潜在的癌症预防成分。儿茶素是6大类黄酮之一，在茶叶中也有高浓度存在。我们的目的是利用兹沃勒老年研究的数据评估儿茶素摄入量与上皮癌发病率之间的关联，该研究是1985年对728名年龄在65 - 84岁男性进行的一项前瞻性队列研究。基线时儿茶素的平均摄入量为72毫克/天（范围为0 - 355毫克/天）。经过10年的随访，记录了96例新发上皮癌病例，包括42例肺癌。经过多变量调整后，儿茶素摄入量与上皮癌（最低三分位数到最高三分位数的风险比[RR]：1.00、0.75、0.94；趋势p值：0.82）或肺癌（最低三分位数到最高三分位数的RR：1.00、0.72、0.92；趋势p值：0.80）均无关联。非茶来源的儿茶素与肺癌发病率呈临界显著负相关（摄入量增加7.5毫克时的RR和95%置信区间[CI]：0.66，0.42 - 1.05），而茶来源的儿茶素则不然。苹果是非茶儿茶素的主要来源，苹果中的儿茶素也与肺癌发病率有关（儿茶素增加7.5毫克时的RR和95% CI：0.67，0.38 - 1.17）。由于该人群中儿茶素的主要来源——茶，与癌症风险无关，所以儿茶素似乎不太可能是观察到的非茶儿茶素与肺癌发病率之间负相关趋势的原因。然而，各种儿茶素生物利用度的差异可能起了作用；对个别癌症部位的影响也不能排除，值得进一步研究。
