Department of Epidemiology, GROW School for Oncology and Developmental Biology,Maastricht University, Maastricht, the Netherlands.
Am J Epidemiol. 2013 Jun 15;177(12):1388-98. doi: 10.1093/aje/kws419. Epub 2013 May 30.
Flavonoids are natural antioxidants found in various foods, and a major source is black tea. Some experimental evidence indicates that flavonoids could prevent prostate cancer. We investigated the associations between flavonoid intake, black tea consumption, and prostate cancer risk in the Netherlands Cohort study, which includes 58,279 men who provided detailed baseline information on several cancer risk factors. From 1986 to 2003, 3,362 prostate cancers were identified, including 1,164 advanced (stage III/IV) cancers. Cox proportional hazards regression using the case-cohort approach was used to estimate hazard ratios and 95% confidence intervals. Intake of total catechin, epicatechin, kaempferol, and myricetin and consumption of black tea were associated with a decreased risk of stage III/IV or stage IV prostate cancer. Hazard ratios of stage III/IV and stage IV prostate cancer for the highest versus the lowest category of black tea consumption (≥5 versus ≤1 cups/day) were 0.75 (95% confidence interval: 0.59, 0.97) and 0.67 (95% confidence interval: 0.50, 0.91), respectively. No associations were observed for overall and nonadvanced prostate cancer. In conclusion, dietary flavonoid intake and black tea consumption were associated with a decreased risk of advanced stage prostate cancer.
类黄酮是存在于各种食物中的天然抗氧化剂，其主要来源是红茶。一些实验证据表明，类黄酮可能预防前列腺癌。我们在荷兰队列研究中调查了类黄酮摄入量、红茶消费与前列腺癌风险之间的关联，该研究纳入了 58279 名男性，他们提供了有关多种癌症风险因素的详细基线信息。在 1986 年至 2003 年间，共确定了 3362 例前列腺癌，其中包括 1164 例晚期（III/IV 期）癌症。使用病例-队列方法的 Cox 比例风险回归用于估计风险比和 95%置信区间。总儿茶素、表儿茶素、山奈酚和杨梅素的摄入量以及红茶的消费与 III/IV 期或 IV 期前列腺癌风险降低相关。红茶消费最高与最低类别（≥5 杯/天与≤1 杯/天）相比，III/IV 期和 IV 期前列腺癌的风险比分别为 0.75（95%置信区间：0.59，0.97）和 0.67（95%置信区间：0.50，0.91）。对于总前列腺癌和非晚期前列腺癌，未观察到相关性。总之，饮食类黄酮摄入量和红茶消费与晚期前列腺癌风险降低相关。
