Goya Luis, Martín María Ángeles, Sarriá Beatriz, Ramos Sonia, Mateos Raquel, Bravo Laura
Departamento de Metabolismo y Nutrición; Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ICTAN - CSIC), José Antonio Novais, 10, Madrid 28040, Spain.
Centro de Investigación Biomédica en red de Diabetes y Enfermedades Metabólicas Asociadas (ISCIII), Madrid 28029, Spain.
Nutrients. 2016 Apr 9;8(4):212. doi: 10.3390/nu8040212.
Chronic inflammation has been identified as a necessary step to mediate atherosclerosis and cardiovascular disease and as a relevant stage in the onset and progression of several types of cancer. Considerable attention has recently been focused on the identification of dietary bioactive compounds with anti-inflammatory activities as an alternative natural source for prevention of inflammation-associated diseases. The remarkable capacity of cocoa flavanols as antioxidants, as well as to modulate signaling pathways involved in cellular processes, such as inflammation, metabolism and proliferation, has encouraged research on this type of polyphenols as useful bioactive compounds for nutritional prevention of cardiovascular disease and cancer. Data from numerous studies suggest that cocoa and cocoa-derived flavanols can effectively modify the inflammatory process, and thus potentially provide a benefit to individuals with elevated risk factors for atherosclerosis/cardiovascular pathology and cancer. The present overview will focus on the most recent findings about the effects of cocoa, its main constituents and cocoa derivatives on selected biomarkers of the inflammatory process in cell culture, animal models and human cohorts.
慢性炎症已被确认为介导动脉粥样硬化和心血管疾病的必要步骤，以及多种癌症发生和发展的相关阶段。最近，相当多的注意力集中在鉴定具有抗炎活性的膳食生物活性化合物，作为预防炎症相关疾病的替代天然来源。可可黄烷醇作为抗氧化剂以及调节参与细胞过程（如炎症、代谢和增殖）的信号通路的显著能力，促使人们对这类多酚进行研究，认为它们是用于营养预防心血管疾病和癌症的有用生物活性化合物。大量研究数据表明，可可和可可衍生的黄烷醇可以有效改变炎症过程，从而可能对动脉粥样硬化/心血管病理和癌症风险因素升高的个体有益。本综述将聚焦于可可及其主要成分和可可衍生物对细胞培养、动物模型和人类队列中炎症过程选定生物标志物影响的最新研究结果。
