Schatteman K, Goossens F, Leurs J, Verkerk R, Scharpé S, Michiels J J, Hendriks D
Laboratory of Medical Biochemistry, University of Antwerp, Belgium.
Clin Appl Thromb Hemost. 2001 Apr;7(2):93-101. doi: 10.1177/107602960100700203.
In 1988, Hendricks et al. first reported on the presence of carboxypeptidase U (U refers to the unstable nature of the enzyme) in human serum. One decade later, the importance of carboxypeptidase U (CPU) in the regulation of fibrin clot dissolution is well documented. CPU circulates in plasma as an inactive zymogen, proCPU, that is converted to its active form during coagulation and fibrinolysis. CPU cleaves off C-terminal lysine residues exposed on fibrin partially degraded by the action of plasmin. Because these C-terminal lysine residues are important for upregulating the fibrinolytic rate, CPU thus slows down fibrinolysis.
1988年，亨德里克斯等人首次报道了人血清中存在羧肽酶U（U指该酶的不稳定性质）。十年后，羧肽酶U（CPU）在纤维蛋白凝块溶解调节中的重要性得到了充分证明。CPU以无活性的酶原proCPU形式在血浆中循环，在凝血和纤维蛋白溶解过程中转化为其活性形式。CPU切割掉纤溶酶作用后纤维蛋白上暴露的C端赖氨酸残基。由于这些C端赖氨酸残基对上调纤维蛋白溶解速率很重要，因此CPU会减缓纤维蛋白溶解。
