Timofeev А V
Russian Research Institute of Haematology and Transfusiology, Saint Petersburg, Russia.
Biomed Khim. 2016 Mar-Apr;62(2):141-9. doi: 10.18097/PBMC20166202141.
This review considers the basic metallocarboxypeptidases of human blood and their role in coagulologic disorders. In includes information on the history of the discovery and biological characteristics of potential enzymes-regulators of the fibrinolytic process: carboxypeptidase U and carboxypeptidase N. Certain attention is paid to the biochemical mechanisms and the main modern concepts of the antifibrinolytic effects of these enzymes.
本综述探讨了人类血液中的基本金属羧肽酶及其在凝血障碍中的作用。其中包括有关纤溶过程潜在酶调节剂——羧肽酶U和羧肽酶N的发现历史和生物学特性的信息。本文还特别关注了这些酶抗纤溶作用的生化机制和主要现代概念。
