单侧肾切除的未成熟大鼠（38525）中额外肾单位的诱导。
Induction of extra nephrons in unilaterally nephrectomized immature rats (38525).
作者信息
Canter C E, Goss R J
出版信息
Proc Soc Exp Biol Med. 1975 Jan;148(1):294-6. doi: 10.3181/00379727-148-38525.
PMID:1129268
Abstract
The normal number of glomeruli per kidney in the rat rises from about 10-4 at birth to approximately 35 times 10-3 at 50 days of age. When one kidney is removed at birth the remaining one produces an average of 63% more nephrons than normal by 70 days. Unilateral nephrectomy of successively older rats results in progressively less augmentation of the nephron complement in the remaining kidney up to 50 days, beyond which age the kidney loses its ability to produce new nephrons.
摘要
大鼠每个肾脏中肾小球的正常数量从出生时的约10⁻⁴增加到50日龄时的约35×10⁻³。出生时切除一侧肾脏，到70日龄时，剩余的肾脏产生的肾单位平均比正常情况多63%。对年龄逐渐增大的大鼠进行单侧肾切除术，直至50日龄，剩余肾脏中肾单位数量的增加逐渐减少，超过这个年龄后，肾脏失去产生新肾单位的能力。
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