Larsson L, Aperia A, Wilton P
Kidney Int. 1980 Jul;18(1):29-35. doi: 10.1038/ki.1980.107.
Sprague-Dawley rats were nephrectomized unilaterally, or sham-operated at 5, 12, and 40 days of age. The kidney weight, number of glomeruli, GFR, and single nephron GFR (SNGFR) were determined in about 60 days of age. In both sham-operated and nephrectomized rats operated on at 5 and 12 days of age, the kidney was studied with light microscope for 1 to 14 days. Unilateral nephrectomy performed just before or just after completion of nephrogenesis or in adulthood did not result in formation of new nephrons. Renal structural development followed the same pattern in nephrectomized and sham-operated rats. A compensatory increase in renal size and GRF was inversely related to the age at which the nephrectomy was carried out but was more pronounced if nephrectomy had been performed just before rather than just after completion of nephrogenesis. In all nephrectomized rats, the compensatory increase in filtration rate appears to be the same in nephrons at all cortical levels judging by comparison of SNGRR and GFR. Conclusion. Compensatory renal growth does not involve the formation of new nephrons in the postnatal kidney of the rat. The potentiation of compensatory changes after nephrectomy at an early age is largely dependent on the development stage of the kidney at the time of nephrectomy.
将Sprague-Dawley大鼠在5日龄、12日龄和40日龄时进行单侧肾切除或假手术。在约60日龄时测定肾脏重量、肾小球数量、肾小球滤过率（GFR）和单肾单位肾小球滤过率（SNGFR）。对5日龄和12日龄接受假手术和肾切除的大鼠，在术后1至14天用光学显微镜对肾脏进行研究。在肾发生完成之前或之后不久或成年期进行单侧肾切除，均不会导致新肾单位的形成。肾切除大鼠和假手术大鼠的肾脏结构发育遵循相同模式。肾脏大小和肾小球滤过率的代偿性增加与肾切除时的年龄呈负相关，但如果在肾发生完成之前而非之后不久进行肾切除，则更为明显。通过比较单肾单位肾小球滤过率（SNGRR）和肾小球滤过率（GFR）判断，在所有肾切除大鼠中，所有皮质水平肾单位的滤过率代偿性增加似乎相同。结论。大鼠出生后肾脏的代偿性肾生长不涉及新肾单位形成。早期肾切除后代偿性变化的增强很大程度上取决于肾切除时肾脏的发育阶段。
