CD8(+) T细胞在人类结核病中对γ干扰素产生的作用。
Contribution of CD8(+) T cells to gamma interferon production in human tuberculosis.
作者信息
Shams H, Wizel B, Weis S E, Samten B, Barnes P F
机构信息
Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler 75708-3154, USA.
出版信息
Infect Immun. 2001 May;69(5):3497-501. doi: 10.1128/IAI.69.5.3497-3501.2001.
Abstract
The proportions of peripheral blood mononuclear cells (PBMC), CD4(+) T cells, and CD8(+) T cells that produce gamma interferon (IFN-gamma) in response to Mycobacterium tuberculosis were markedly reduced in tuberculosis patients, particularly in those with severe disease. Depletion of CD4(+) but not CD8(+) cells prior to stimulation of PBMC with M. tuberculosis abolished IFN-gamma production. These results show that (i) IFN-gamma production by CD8(+) and CD4(+) cells correlates with the clinical manifestations of M. tuberculosis infection and (ii) IFN-gamma production by CD8(+) cells depends on CD4(+) cells.
摘要
结核病患者中，因结核分枝杆菌刺激而产生γ干扰素（IFN-γ）的外周血单个核细胞（PBMC）、CD4(+) T细胞和CD8(+) T细胞的比例显著降低，尤其是重症患者。在用结核分枝杆菌刺激PBMC之前去除CD4(+) 细胞而非CD8(+) 细胞，可消除IFN-γ的产生。这些结果表明：（i）CD8(+) 和CD4(+) 细胞产生IFN-γ与结核分枝杆菌感染的临床表现相关；（ii）CD8(+) 细胞产生IFN-γ依赖于CD4(+) 细胞。
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1
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J Immunol. 2000 Jul 1;165(1):353-63. doi: 10.4049/jimmunol.165.1.353.
2
Relative contributions of distinct MHC class I-dependent cell populations in protection to tuberculosis infection in mice.
Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4204-8. doi: 10.1073/pnas.97.8.4204.
3
Depressed T-cell interferon-gamma responses in pulmonary tuberculosis: analysis of underlying mechanisms and modulation with therapy.
J Infect Dis. 1999 Dec;180(6):2069-73. doi: 10.1086/315114.
4
Dichotomy of cytokine profiles in patients and high-risk healthy subjects exposed to tuberculosis.
Infect Immun. 1999 Nov;67(11):5597-603. doi: 10.1128/IAI.67.11.5597-5603.1999.
5
Characterization of human Mycobacterium bovis bacille Calmette-Guérin-reactive CD8+ T cells.
Infect Immun. 1999 Oct;67(10):5223-30. doi: 10.1128/IAI.67.10.5223-5230.1999.
6
Early emergence of CD8(+) T cells primed for production of type 1 cytokines in the lungs of Mycobacterium tuberculosis-infected mice.
Infect Immun. 1999 Aug;67(8):3980-8. doi: 10.1128/IAI.67.8.3980-3988.1999.
7
In vitro synthesis of interferon-gamma, interleukin-4, transforming growth factor-beta and interleukin-1 beta by peripheral blood mononuclear cells from tuberculosis patients: relationship with the severity of pulmonary involvement.
Scand J Immunol. 1999 Feb;49(2):210-7. doi: 10.1046/j.1365-3083.1999.00492.x.
8
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An antimicrobial activity of cytolytic T cells mediated by granulysin.
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