2型糖尿病中的餐后代谢紊乱与心血管疾病
Postprandial dysmetabolism and cardiovascular disease in type 2 diabetes.
作者信息
Tushuizen M E, Diamant M, Heine R J
机构信息
Department of Endocrinology/Diabetes Centre, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands.
出版信息
Postgrad Med J. 2005 Jan;81(951):1-6. doi: 10.1136/pgmj.2004.020511.
Abstract
The worldwide prevalence of type 2 diabetes mellitus has reached epidemic proportions. The so-called traditional risk factors cannot fully explain the excessive cardiovascular disease risk of type 2 diabetic patients. Numerous studies indicate that postprandial metabolic derangements, most notably hyperglycaemia and hypertriglyceridaemia, which are exaggerated and prolonged in type 2 diabetes, are important cardiovascular disease risk factors since they induce oxidative stress and endothelial dysfunctions. This review discusses the current evidence showing that postprandial dysmetabolism may indeed constitute an important cardiovascular disease risk factor as well as the mechanisms underlying this association. Finally, some possible therapeutic options and recommendations for future research are discussed.
摘要
2型糖尿病在全球的患病率已达到流行程度。所谓的传统风险因素并不能完全解释2型糖尿病患者过高的心血管疾病风险。大量研究表明，餐后代谢紊乱，最显著的是高血糖和高甘油三酯血症，在2型糖尿病中会加剧并持续更长时间，它们是重要的心血管疾病风险因素，因为它们会引发氧化应激和内皮功能障碍。本综述讨论了当前的证据，这些证据表明餐后代谢异常可能确实构成重要的心血管疾病风险因素以及这种关联背后的机制。最后，还讨论了一些可能的治疗选择和对未来研究的建议。
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