Margaretten W, McKay D G
J Exp Med. 1969 Mar 1;129(3):585-90. doi: 10.1084/jem.129.3.585.
Rabbits were injected with an antiplatelet serum to produce selective thrombocytopenia without inducing a significant alteration of their leukocyte counts. Thrombocytopenic levels persisted for 8 hr after the injection of platelet antiserum. During this time, the generalized Shwartzman reaction could not be provoked with the second injection of endotoxin. Since platelet phospholipid is required for the formation of plasma thromboplastin, the results indicate that platelets are essential to the evolution of the generalized Shwartzman reaction and endotoxin triggers the intrinsic rather than the extrinsic clotting system to elicit the lesions.
给兔子注射抗血小板血清以产生选择性血小板减少症，而不引起其白细胞计数的显著改变。注射血小板抗血清后，血小板减少水平持续8小时。在此期间，第二次注射内毒素不能引发全身性施瓦茨曼反应。由于血浆凝血活酶的形成需要血小板磷脂，结果表明血小板对于全身性施瓦茨曼反应的发展至关重要，并且内毒素触发内源性而非外源性凝血系统以引发病变。
