Nolan L P, Heatley M K
Department of Histopathology, Royal Liverpool & Broadgreen, University Hospitals, 5th Floor Duncan Building, Prescott Street, Liverpool, L69 3BX, England.
Int J Gynecol Pathol. 2001 Apr;20(2):155-9. doi: 10.1097/00004347-200104000-00007.
Renal clear cell carcinoma rarely metastasizes to the ovary potentially mimicking a primary ovarian clear cell carcinoma. The immunocytochemical profiles of the two tumors were compared. Control groups of ovarian endometrioid and serous adenocarcinomas were also examined using the same antibody panel. Paraffin sections were studied with the immunocytochemical technique using eight antibodies. Renal clear cell carcinomas were positive for vimentin (8/12 cases), CK5/6 (0/12), 34 beta E12 (1/12), Ber-Ep4 (5/12), CA125 (0/12), ER (1/12), and PGR (1/12). Ovarian clear cell carcinomas showed positivity with vimentin (1/10 cases), CK5/6 (2/10), 34 beta E12 (10/10), Ber-Ep4 (10/10), CA125 (8/10), ER (7/10), and PGR (6/10). Endometrioid adenocarcinomas were positive for vimentin (9/10 cases), CK5/6 (8/10), 34 beta E12 (10/10), Ber-Ep4 (9/10), CA125 (9/10), ER (9/10), and PGR (10/10). Eight serous adenocarcinomas were positive in all cases for all the antibodies except CK5/6 (7/8 cases) and 34 beta E12 (7/8 cases). All the tumors reacted for epithelial membrane antigen. This immunohistochemical panel allows clear cell carcinomas of kidney and ovary to be distinguished. The latter has a greater phenotypic similarity with serous and endometrioid adenocarcinomas than with renal clear cell carcinoma demonstrating yet again that these ovarian tumors share a common histogenetic origin.
肾透明细胞癌很少转移至卵巢，可能会被误诊为原发性卵巢透明细胞癌。本研究比较了这两种肿瘤的免疫细胞化学特征。同时，使用相同的抗体组合检测了卵巢子宫内膜样癌和浆液性腺癌对照组。采用免疫细胞化学技术，使用8种抗体对石蜡切片进行研究。肾透明细胞癌波形蛋白阳性（8/12例）、CK5/6阴性（0/12）、34βE12阳性（1/12）、Ber-Ep4阳性（5/12）、CA125阴性（0/12）、雌激素受体（ER）阳性（1/12）、孕激素受体（PGR）阳性（1/12）。卵巢透明细胞癌波形蛋白阳性（1/10例）、CK5/6阳性（2/10）、34βE12阳性（10/10）、Ber-Ep4阳性（10/10）、CA125阳性（8/10）、ER阳性（7/10）、PGR阳性（6/10）。子宫内膜样腺癌波形蛋白阳性（9/10例）、CK5/6阳性（8/10）、34βE12阳性（10/10）、Ber-Ep4阳性（9/10）、CA125阳性（9/10）、ER阳性（9/10）、PGR阳性（10/10）。8例浆液性腺癌除CK5/6（7/8例）和34βE12（7/8例）外，所有抗体检测均为阳性。所有肿瘤上皮膜抗原均呈阳性。该免疫组织化学检测有助于区分肾和卵巢的透明细胞癌。卵巢透明细胞癌与浆液性和子宫内膜样腺癌在表型上的相似性高于肾透明细胞癌，再次表明这些卵巢肿瘤具有共同的组织发生学起源。
