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双氯芬酸新糖基衍生物与双氯芬酸对大鼠胃肠道黏膜的刺激作用比较

Irritation of gastrointestinal mucosa by new glycosyl derivative of diclofenac in comparison with diclofenac in rats.

作者信息

Borowiecka J, Pakulska W, Graczyk J, Wagrowska-Danilewicz M

机构信息

Laborartory of Organic Chemistry, Institute of Chemistry, Chair of Pharmacology, Medical University of Łódź, 90-151 Łódź, 1 Muszyńskiego Str., Poland.

出版信息

Acta Pol Pharm. 2000 Nov;57 Suppl:99-102.

PMID:11293281
Abstract

We have obtained new glycosyl derivative of diclofenac 3 and studied its ulcerogenic effect in the gastrointestinal system. Diclofenac as free acid 1 and its derivative 3 were administered to rats per os in a single dose 20 mg/kg and in 5 doses of 5 mg/kg. Single dose of derivative 3 caused less irritation than 1; after multiple administration no irritating effect of derivative 3 was seen.

摘要

我们已获得双氯芬酸3的新糖基衍生物，并研究了其在胃肠道系统中的致溃疡作用。将游离酸形式的双氯芬酸1及其衍生物3以20mg/kg的单剂量和5mg/kg的5个剂量经口给予大鼠。衍生物3的单剂量引起的刺激比1小；多次给药后未观察到衍生物3的刺激作用。

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