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醋氯芬酸与双氯芬酸抗炎作用及胃肠道耐受性的比较。

Comparison of the anti-inflammatory effect and gastrointestinal tolerability of aceclofenac and diclofenac.

作者信息

Arañó A, Zapatero M I, Basi N, Duque A, Gropper S

机构信息

Centro de Investigación y Desarrollo Aplicado, S.A.L., Barcelona, Spain.

出版信息

Arzneimittelforschung. 1996 Apr;46(4):398-400.

PMID:8740087
Abstract

Aceclofenac (CAS 89796-99-6) and diclofenac (CAS 15307-79-6) are orally effective non-steroidal anti-inflammatory drugs. Their anti-inflammatory and potential gastrointestinal damaging effects were compared following single and repeated administration (5 days). Both drugs exerted an anti-inflammatory activity and showed a similar gastrointestinal tolerability in the rat.

摘要

醋氯芬酸(CAS 89796-99-6)和双氯芬酸(CAS 15307-79-6)是口服有效的非甾体抗炎药。在单次和重复给药(5天)后,对它们的抗炎作用和潜在的胃肠道损伤作用进行了比较。两种药物均具有抗炎活性,并且在大鼠中显示出相似的胃肠道耐受性。

相似文献

1
Comparison of the anti-inflammatory effect and gastrointestinal tolerability of aceclofenac and diclofenac.醋氯芬酸与双氯芬酸抗炎作用及胃肠道耐受性的比较。
Arzneimittelforschung. 1996 Apr;46(4):398-400.
2
Pharmacology of the potent new non-steroidal anti-inflammatory agent aceclofenac.新型强效非甾体抗炎药醋氯芬酸的药理学
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Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative, on carrageenan-induced hindpaw oedema formation in the rat.新型硫化氢释放衍生物S-双氯芬酸对角叉菜胶诱导的大鼠后爪水肿形成的影响。
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Acute anti-inflammatory activity and gastrointestinal tolerability of diclofenac and nitrofenac.双氯芬酸和硝芬酸的急性抗炎活性及胃肠道耐受性
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Synthesis, characterization, and biological evaluation of novel diclofenac prodrugs.新型双氯芬酸前药的合成、表征及生物学评价。
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Interaction of allopurinol and non-steroidal anti-inflammatory drugs on the carrageenan-induced rat paw edema.别嘌醇与非甾体抗炎药对角叉菜胶诱导的大鼠足爪水肿的相互作用。
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Irritation of gastrointestinal mucosa by new glycosyl derivative of diclofenac in comparison with diclofenac in rats.双氯芬酸新糖基衍生物与双氯芬酸对大鼠胃肠道黏膜的刺激作用比较
Acta Pol Pharm. 2000 Nov;57 Suppl:99-102.

引用本文的文献

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Safety and effectiveness of 4-week therapy with aceclofenac controlled release once a day.一天一次服用醋氯芬酸控释片 4 周的安全性和有效性。
Sci Rep. 2022 Oct 3;12(1):16519. doi: 10.1038/s41598-022-20633-6.
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Aceclofenac: a reappraisal of its use in the management of pain and rheumatic disease.醋氯芬酸:对其在疼痛和风湿性疾病管理中应用的重新评估
Drugs. 2001;61(9):1351-78. doi: 10.2165/00003495-200161090-00012.