克氏锥虫在裸鼠体内大量发育出血液型锥鞭毛体。
Development of high numbers of blood trypomastigotes of Trypanosoma cruzi in nude rats.
作者信息
Schaub G A, Hölscher C, Mossmann H
机构信息
Department of Special Zoology, Ruhr University, Bochum, Germany.
出版信息
Parasitol Res. 2001 Mar;87(3):245-7. doi: 10.1007/s004360000342.
The development and pathogenicity of a Trypanosoma cruzi strain ("Chile 5") of low virulence were studied after infection of nude rats with different doses of blood trypomastigotes (10-10(7) parasites/rat). Peak parasitemias were correlated with the infection dose, which also influenced the mean survival times (26-36 days post-infection). Within 26 or 27 days, a subcutaneous injection of 10(7) blood trypomastigotes developed to about 8-20 x 10(7) parasites/ml.
用不同剂量的血液型锥鞭毛体（每只大鼠10 - 10⁷个寄生虫）感染裸鼠后，研究了低毒力克氏锥虫菌株（“智利5号”）的发育和致病性。最高虫血症与感染剂量相关，感染剂量也影响平均存活时间（感染后26 - 36天）。在26或27天内，皮下注射10⁷个血液型锥鞭毛体后，寄生虫数量发展到约8 - 20×10⁷个/毫升。
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