Miyahara Y, Hibasami H, Katsuzaki H, Imai K, Osawa T, Ina K, Komiya T
Kuki Sangyo Co., Ltd., Yokkaichi-city, Mie 510-0059, Japan.
Int J Mol Med. 2001 May;7(5):485-8.
The exposure of human lymphoid leukemia Molt 4B cells to sesaminol, a component of sesame oil led to both growth inhibition and the induction of apoptosis. Morphological change showing apoptotic bodies was observed in the cells treated with sesaminol. The fragmentation of DNA by sesaminol to oligonucleosomal-sized fragments that are characteristics of apoptosis was observed to be concentration- and time-dependent. These findings suggest that growth inhibition of Molt 4B cells by sesaminol results from the induction of apoptosis in the cells.
将人淋巴白血病Molt 4B细胞暴露于芝麻油的成分芝麻素中，会导致细胞生长抑制并诱导细胞凋亡。在用芝麻素处理的细胞中观察到呈现凋亡小体的形态变化。观察到芝麻素将DNA切割成凋亡特征性的寡核小体大小的片段，这一过程具有浓度和时间依赖性。这些发现表明，芝麻素对Molt 4B细胞的生长抑制是由诱导细胞凋亡所致。
