Hibasami H, Achiwa Y, Katsuzaki H, Imai K, Yoshioka K, Nakanishi K, Ishii Y, Hasegawa M, Komiya T
Faculty of Medicine, Mie University, Japan.
Int J Mol Med. 1998 Dec;2(6):671-3. doi: 10.3892/ijmm.2.6.671.
The exposure of human lymphoid leukemia Molt 4B cells to honokiol led to both growth inhibition and the induction of apoptosis. Morphological change showing apoptotic bodies was observed in the cells treated with honokiol. The fragmentation by honokiol of DNA to oligonucleosomal-sized fragments that are characteristics of apoptosis was observed to be concentration- and time-dependent. These findings suggest that growth inhibition by honokiol of Molt 4B cells results from the induction of apoptosis in the cells.
将人淋巴白血病Molt 4B细胞暴露于厚朴酚会导致生长抑制并诱导细胞凋亡。在用厚朴酚处理的细胞中观察到显示凋亡小体的形态变化。观察到厚朴酚将DNA片段化为凋亡特征性的寡核小体大小的片段，这呈浓度和时间依赖性。这些发现表明，厚朴酚对Molt 4B细胞的生长抑制是由细胞凋亡的诱导引起的。
