Miyahara Y, Hibasami H, Katsuzaki H, Imai K, Komiya T
Kuki Sangyo Co., Ltd., 11 Onoue-cho, Yokkaichi-city, Mie 510-0059, Japan.
Int J Mol Med. 2001 Apr;7(4):369-71.
The exposure of human lymphoid leukemia Molt 4B cells to sesamolin, a component of sesame seed led to both growth inhibition and the induction of apoptosis. Morphological change showing apoptotic bodies was observed in the cells treated with sesamolin. The fragmentation of DNA by sesamolin to oligonucleosomal-sized fragments that are characteristics of apoptosis was observed to be concentration- and time-dependent. These findings suggest that growth inhibition of Molt 4B cells by sesamolin results from the induction of apoptosis in the cells.
将人淋巴白血病Molt 4B细胞暴露于芝麻籽的成分芝麻林素中，会导致细胞生长抑制和凋亡诱导。在用芝麻林素处理的细胞中观察到了显示凋亡小体的形态变化。芝麻林素将DNA片段化为凋亡特征性的寡核小体大小的片段，这种现象呈浓度和时间依赖性。这些发现表明，芝麻林素对Molt 4B细胞的生长抑制是由细胞凋亡诱导所致。
