Yokel R A, Rhineheimer S S, Brauer R D, Sharma P, Elmore D, McNamara P J
Pharmacy Building, College of Pharmacy, University of Kentucky Medical Center, Lexington, KY 40536-0082, USA.
Toxicology. 2001 Mar 21;161(1-2):93-101. doi: 10.1016/s0300-483x(01)00335-3.
The objectives were to estimate aluminum (Al) oral bioavailability under conditions that model its consumption in drinking water, and to test the hypotheses that stomach contents and co-administration of the major components of hard water affect Al absorption. Rats received intragastric 26Al in the absence and presence of food in the stomach and with or without concomitant calcium (Ca) and magnesium (Mg) at concentrations found in hard drinking water. The use of 26Al enables the study of Al pharmacokinetics at physiological Al concentrations without interference from 27Al in the environment or the subject. 27Al was intravenously administered throughout the study. Repeated blood withdrawal enabled determination of oral 26Al bioavailability from the area under its serum concentrationxtime curve compared to serum 27Al concentration in relation to its infusion rate. Oral Al bioavailability averaged 0.28%. The presence of food in the stomach and Ca and Mg in the water that contained the orally dosed 26Al appeared to delay but not significantly alter the extent of 26Al absorption. The present and published results suggest oral bioavailability of Al from drinking water is very low, about 0.3%. The present results suggest it is independent of stomach contents and water hardness.
研究目的是在模拟饮用水中铝摄入情况的条件下，评估铝的口服生物利用度，并检验胃内容物以及与硬水中主要成分同时给药会影响铝吸收这两个假设。在胃中有食物和没有食物的情况下，以及在有或没有硬饮用水中所含浓度的钙（Ca）和镁（Mg）伴随的情况下，给大鼠进行胃内注射26Al。使用26Al能够在生理铝浓度下研究铝的药代动力学，而不受环境或实验对象中27Al的干扰。在整个研究过程中，给大鼠静脉注射27Al。通过反复采血，与静脉输注速率相关的血清27Al浓度相比，根据血清浓度-时间曲线下的面积来测定口服26Al的生物利用度。口服铝的生物利用度平均为0.28%。胃中存在食物以及含有口服给药26Al的水中存在Ca和Mg，似乎会延迟但不会显著改变26Al的吸收程度。目前的研究结果和已发表的结果表明，饮用水中铝的口服生物利用度非常低，约为0.3%。目前的研究结果表明，它与胃内容物和水的硬度无关。
