Babu B H, Shylesh B S, Padikkala J
Amala Cancer Research Centre, Amala Nagar, -680 553, Thrissur, India.
Fitoterapia. 2001 Mar;72(3):272-7. doi: 10.1016/s0367-326x(00)00300-2.
The alcoholic extract of Acanthus ilicifolius leaves inhibited the formation of oxygen derived free radicals (ODFR) in vitro with IC(50) of 550 microg/ml, 2750 microg/ml, 670 microg/ml and 600 microg/ml (Fe(2+)/ascorbate system), 980 microg/ml (Fe(3+)/ADP/ascorbate system) for superoxide radical production, hydroxyl radical generation, nitric oxide radical formation and lipid peroxide formation, respectively. The oral administration of the extract (250 and 500 mg/kg) significantly reduced CCl(4) induced hepatotoxicity in rats, as judged from the serum and tissue activity of marker enzymes [glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT) and alkaline phosphatase (ALP)]. These results were comparable with those obtained with curcumin (100 mg/kg, p.o.).
老鼠簕叶的乙醇提取物在体外抑制氧衍生自由基（ODFR）的形成，对于超氧阴离子自由基产生、羟基自由基生成、一氧化氮自由基形成和脂质过氧化物形成，其IC(50)分别为550微克/毫升、2750微克/毫升、670微克/毫升和600微克/毫升（Fe(2+)/抗坏血酸体系），980微克/毫升（Fe(3+)/ADP/抗坏血酸体系）。从标记酶[谷草转氨酶（GOT）、谷丙转氨酶（GPT）和碱性磷酸酶（ALP）]的血清和组织活性判断，提取物经口给药（250和500毫克/千克）可显著降低CCl(4)诱导的大鼠肝毒性。这些结果与用姜黄素（100毫克/千克，口服）获得的结果相当。
