没食子酸甲酯通过抑制活性氧生成对叔丁基过氧化氢诱导的氧化应激的抗氧化活性及保护作用。
Antioxidant activity and protective effect of methyl gallate against -BHP induced oxidative stress through inhibiting ROS production.
作者信息
Ryu Bo-Im, Kim Ki-Tae
机构信息
Department of Applied Life Science, Konkuk University, Chungju, 27478 Korea.
Department of Korean Medicine, Semyung University, Jecheon, 27136 Korea.
出版信息
Food Sci Biotechnol. 2022 Jun 27;31(8):1063-1072. doi: 10.1007/s10068-022-01120-0. eCollection 2022 Jul.
Abstract
Non-alcoholic fatty liver disease (NAFLD) is one of the major diseases of chronic liver damage caused by oxidative stress. In this study, we investigated hepatoprotective effect of methyl gallate (MG) against -BHP induced oxidative stress. Our results revealed that MG possessed strong antioxidant activity and lipid peroxidation inhibitory activity. In addition, MG inhibited -BHP induced cell cytotoxicity, ROS production and sub-G1 phase cells in Chang liver cells. MG attenuated also activated signal p38 and decreased mitochondrial-mediated cell death by regulating pro- and anti- apoptotic proteins. Our results indicate that MG could be potentially used as protective agent in NAFLD therapy by modulating oxidative stress.
摘要
非酒精性脂肪性肝病（NAFLD）是由氧化应激引起的慢性肝损伤的主要疾病之一。在本研究中，我们研究了没食子酸甲酯（MG）对叔丁基过氧化氢（-BHP）诱导的氧化应激的肝保护作用。我们的结果表明，MG具有很强的抗氧化活性和脂质过氧化抑制活性。此外，MG抑制了-BHP诱导的Chang肝细胞的细胞毒性、活性氧（ROS）产生和亚G1期细胞。MG还通过调节促凋亡蛋白和抗凋亡蛋白，减弱了激活的信号p38并减少了线粒体介导的细胞死亡。我们的结果表明，MG通过调节氧化应激，有可能作为NAFLD治疗中的保护剂。
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