一氧化碳清除

Carbon monoxide elimination.

作者信息

Wagner J A, Horvath S M, Dahms T E

出版信息

Respir Physiol. 1975 Jan;23(1):41-7. doi: 10.1016/0034-5687(75)90070-5.

Abstract

The elimination rates of carbon monoxide in anesthetized, spontaneously breathing dogs were determined following acute inhalation of varying amounts of this gas. Blood levels of carboxyhemoglobin (COHb) induced ranged between 5 and 43%. Following the administration of carbon monoxide, the decline in arterial blood %COHb was biphasic. The decline in the blood %COHb level could be described as an initial distribution curve which was exponential in nature, followed by an elimination curve which was linear for 90 min. Prediction equations for elimination of CO from blood according to the initial levels of COHb are presented. Animals having low (5-16%) and high (20-43%) COHb levels eliminated 50% of their total load in 190 plus or minus 6.4 and 134 plus or minus 5.3 min, respectively.

摘要

在麻醉且自主呼吸的犬类中，吸入不同量的一氧化碳后，测定了一氧化碳的清除率。诱导产生的碳氧血红蛋白（COHb）血液水平在5%至43%之间。给予一氧化碳后，动脉血中COHb百分比的下降呈双相性。血液中COHb水平的下降可描述为一条本质上呈指数形式的初始分布曲线，随后是一条在90分钟内呈线性的清除曲线。给出了根据COHb初始水平从血液中清除CO的预测方程。COHb水平低（5%-16%）和高（20%-43%）的动物分别在190±6.4分钟和134±5.3分钟内清除了其总负荷的50%。