Fulton A B, Hansen R M, Petersen R A, Vanderveen D K
Department of Ophthalmology, Children's Hospital, 300 Longwood Ave, Boston, MA 02115, USA.
Arch Ophthalmol. 2001 Apr;119(4):499-505. doi: 10.1001/archopht.119.4.499.
To test the hypothesis that the more severe the acute phase retinopathy of prematurity (ROP) was in the preterm weeks, the more severely compromised is rod photoreceptor function after the ROP has resolved.
Electroretinographic (ERG) responses were recorded from 25 dark-adapted children (ages 2.5 months' postterm to 14 years) categorized by maximum, acute phase ROP (None to Very Severe). From the ERG a-wave "S," a sensitivity parameter for the rod photoreceptor response, and R(mp3), the saturated amplitude of the rod photoreceptor response were calculated using a model of the activation of rod phototransduction. The patients' results were compared with those of healthy controls (n = 71).
Among those in the None, Mild, Moderate, and Severe categories, both S and R(mp3) varied significantly with severity of acute phase ROP. In the Very Severe category, ERG responses were too attenuated to calculate S and R(mp3).
The rod photoreceptors must be involved in ROP. The more severe the acute phase ROP, the more severe is the compromise of the processes involved in the activation of phototransduction in the rods.
验证以下假设，即早产儿急性视网膜病变（ROP）在早产几周时越严重，ROP消退后视杆光感受器功能受损就越严重。
对25名暗适应儿童（足月后2.5个月至14岁）进行视网膜电图（ERG）记录，这些儿童根据ROP急性期的严重程度（无至非常严重）进行分类。利用视杆光转导激活模型，从ERG的a波“S”（视杆光感受器反应的敏感性参数）和R(mp3)（视杆光感受器反应的饱和振幅）进行计算。将患者的结果与健康对照组（n = 71）的结果进行比较。
在无、轻度、中度和重度类别中，S和R(mp3)均随急性期ROP的严重程度而有显著变化。在非常严重类别中，ERG反应过于衰减，无法计算S和R(mp3)。
视杆光感受器必定参与了ROP。急性期ROP越严重，视杆中光转导激活过程受损就越严重。
